Agomelatine 1 Gram Pharmaceutical Grade Powder
₦68,572.00
What is Agomelatine?Agomelatine is a nootropic compound with the potential to elicit antidepressant effects by acting as a melatonergic agonist for MT1 and MT2 receptors, as well as serotonergic antagonist for 5-HT2C receptors. Previous research has found that agomelatine improves symptoms of depression related to unpredictable stress by affecting the levels of brain-derived neurotrophic factor
Description
About the Product 🔑
| Feature | Description |
| Compound Properties 🧪 | Agomelatine 1 gram, a potent compound for research. |
| Handling ⚠️ | Handle with care and ensure safety protocols are followed. |
| Medication Uses 💊 | Agomelatine medication, uses for depression and anxiety. |
| Dosage Information 📏 | Dosage guidelines. |
| Side Effects 🤕 | Side effects. |
| Comparison ⚖️ | How it compares to other antidepressants. |
| Product Format 📦 | Agomelatine 25mg Per Dry-Fill Capsule 60 Count Dry-Fill Capsule 1.5g. |
| Usage Restriction 🚫 | Sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. |
| Terms Acknowledgment ✅ | Please familiarize yourself with our Terms and Conditions prior to ordering. |
Product Benefits 💡
| Benefit | Description |
| Mood Regulation 😊 | By regulating circadian rhythms, improving sleep quality, and modulating mood, agomelatine helps alleviate depressive symptoms. |
| Symptom Relief 😌 | Helps alleviate depressive symptoms such as sadness, loss of interest or pleasure, changes in appetite or weight, sleep disturbances, fatigue, feelings of worthlessness or guilt, and difficulty concentrating or making decisions. |
| Antidepressant Effect 🧠 | Potential to elicit antidepressant effects by acting as a melatonergic agonist for MT1 and MT2 receptors, as well as serotonergic antagonist for 5-HT2C receptors. |
| Neurotrophic Factor Impact 🌟 | Improves symptoms of depression related to unpredictable stress by affecting the levels of brain-derived neurotrophic factor in the hippocampus. |
| Inflammatory Signaling Suppression 🛡️ | Treatment with agomelatine was found to prevent comorbid depression by suppressing inflammatory signaling in a model of acquired epilepsy. |
| No Adverse Sexual Effects 🚫 | Treatment with agomelatine was found to have antidepressant effects on test subjects without eliciting any adverse effects on sexual behavior or development. |
How to Use 🛠️
- Step 1: ✋ Agomelatine (say: ag-o-mell-a-teen).
- Step 2: 💊 What is agomelatine used for? Agomelatine (Valdoxan®) is used to help treat the symptoms of depression.
- Step 3: ⏳ It helps by reducing the time it takes to recover and to help stop the symptoms coming back.
- Step 4: 📝 It is made as tablets.
- Step 5: 📏 What is the usual dose of agomelatine? Learn about Agomelatine medication, its uses for depression and anxiety, dosage guidelines.
Ingredients 🧴
| Ingredient | Description |
| Agomelatine | Nootropic compound 🧠 |
| Melatonergic Agonist | MT1 and MT2 receptors ✨ |
| Serotonergic Antagonist | 5-HT2C receptors 🚦 |
| Brain-Derived Neurotrophic Factor | Hippocampus support 🌱 |
| Hydroxyethyl cellulose | Vehicle substance 🧪 |
Product Details 🏷️
| Details | Information |
| Research Finding 1 🔬 | Treatment with agomelatine was found to prevent comorbid depression by suppressing inflammatory signaling in a model of acquired epilepsy. |
| Research Finding 2 🌟 | Treatment with agomelatine was found to have antidepressant effects on test subjects without eliciting any adverse effects on sexual behavior or development. |
| Study Setup 🐀 | Adult male Wistar rats weighing 200-230 grams each were utilized. The test subjects were housed 3-4 to a cage and were maintained under standard laboratory conditions with free access to food and water. |
| Status Epilepticus Induction ⚡ | Status epilepticus was induced in the rats through an injection of kainate acid, following the injection the rats were kept in individual cages in order for the research team to monitor and record occurrences of spontaneous motor seizures through the use of 24 hour video recording and EEG monitoring. |
| Kainate Acid Injection 💉 | Kainate acid was intraperitoneally injected at a dose of 5 mg/kg, followed by a half-dose of 2.5 mg/kg, 1 hour later. |
| Racine’s Scale Use 📏 | A modified Racine’s scale was used in order for the researchers to monitor the intensity of the seizures. Class I and class II partial seizures characterized by immobility, facial automatism, head nodding, and wet-dog shakes were not scored. |
| Seizure Intensity Scoring 📊 | Additional injections of kainate acid were based on the detection of class III seizures defined by forelimb clonus with lordotic posture, class IV seizures defined by rearing and continued forelimb clonus, and class V seizures defined by forelimb clonus and loss of posture. Seizure intensity determined whether a half-dose of kainate acid should be injected or whether administered should be discontinued. |
| Status Epilepticus Onset ⏳ | The onset of status epilepticus was characterized by the occurrence of >9 sustained motor seizures per hour; onset typically required between 3 and 4 doses of kainate acid. |
| Experimental Treatment Groups 🧑🔬 | After kainate acid-induction of status epilepticus, the animals were randomly divided into four different experimental treatment groups. Group 1 included control rats treated with the vehicle substance, hydroxyethyl cellulose; group 2 included control rats treated with agomelatine; group 3 included rats injected with kainate acid and treated with a hydroxyethyl cellulose; and group 4 included rats injected with kainate acid and treated with agomelatine. |
| Agomelatine Injection Dosage 🥄 | Agomelatine was intraperitoneally injected at a dose of 40 mg/kg dissolved in hydroxyethyl cellulose, 1 hour after status epilepticus was induced via kainate acid. |
| Daily Treatment Regimen 🗓️ | After the first initial dose of the nootropic, all surviving test subjects included in the group administered both kainate acid and agomelatine continued treatment for 10 weeks receiving the same 40 mg/kg dose on a daily basis. |
| Neuroprotective Effect Timing ⏰ | It is important to mention that the neuroprotective effects of agomelatine was shown to be most potent within 1 hour of administration. |
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Product Standout Benefits
We offer a high purity natural product in bulk grade. The quality of this product is the BEST among Chinese suppliers! We maintain high quality standards and ensure sufficient purity. We can provide batch quality inspection, such as NMR, HPLC, and other testing reports. We supply over 8000 high purity natural products from TCM for analysis, standard research, from mg to kg. We expect to establish long-term cooperative relations with various customers around the world and look forward to mutual benefits and shared growth. We also offer natural products and OEM of high purity natural products from mg to kg. Expect BIGGER Orders & SUPER Surprise Prices.
Key Features:
- High Purity Natural Products
- Bulk Grade Supply
- BEST Quality Among Chinese Suppliers
- Batch Quality Inspection Reports (NMR, HPLC)
- Supply from mg to kg
- OEM Available
Customer Questions and Answers
Q: What are the key ingredients and purity of this product? 🤔
A: The main ingredient is Agomelatine, with CAS number 138112-76-2. It boasts a purity of 99+%.
Q: What kind of quality assurance is provided? 🌟
A: We can provide batch quality inspection, such as NMR, HPLC, and other testing reports to ensure the quality of our products.
Q: What quantities are available? ⚖️
A: We supply natural products from mg to kg, catering to analysis and standard research needs. We also offer OEM of high purity natural products from mg to kg.
Q: What is the physical form of the product? 🧊
A: The product has a melting point of 107-109°C.
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